Automated, high-throughput applied sciences have gotten more and more frequent in microbiome research to lower prices and improve effectivity. Nevertheless, in microbiome research, small variations in methodology – together with storage situations, moist lab strategies, sequencing platforms and knowledge evaluation – can affect the reproducibility and comparability of knowledge throughout research. There was restricted testing of the results of high-throughput strategies, together with microfluidic PCR applied sciences.
On this paper, we evaluate two extraction strategies (the QIAamp DNA Stool Mini Equipment and the MoBio PowerSoil DNA Isolation package), two taq polymerase enzymes (MyTaq HS Purple Combine and Accustart II PCR ToughMix), two primer units (V3-V4 and V4-V5) and two amplification strategies (a typical two-step PCR protocol and amplicon library preparation on the Fluidigm Entry Array system that permits automated multiplexing of primers). Intestine microbial group profiles had been considerably affected by all variables. Whereas there have been no vital variations in alpha range measured between the 2 extraction strategies, there was an impact of extraction technique on group composition measured by unweighted UniFrac distances. Each amplification technique and primers had a big impact on each alpha range and group composition.
The relative abundance of Actinobacteria was considerably decrease when utilizing the MoBio package or Fluidigm amplification technique, and the relative abundance of Firmicutes was decrease when utilizing the Qiagen package. Microbial group profiles based mostly on Fluidigm-generated amplicon libraries weren’t corresponding to these generated with extra generally used strategies. Researchers ought to fastidiously contemplate the constraints and biases that completely different extraction and amplification strategies can introduce into their outcomes. Moreover, extra thorough benchmarking of automated and multiplexing strategies is critical to find out the magnitude of the potential trade-off between the standard and the amount of knowledge.
Diagnostic approaches in COVID-19: medical updates
Introduction: COVID-19 is a current rising pandemic whose prognosis continues to be unclear. Diagnostic instruments are the principle gamers that not solely point out a potential an infection however can additional limit the transmission and might decide the extent to which illness development would happen.
Areas lined: On this paper, we’ve carried out a story and demanding evaluation on completely different expertise-based diagnostic methods resembling molecular approaches together with real-time reverse transcriptase, serological testing by enzyme-linked immunosorbent assay, laboratory and level of care gadgets, radiology-based detection by computed tomography & chest X-ray, and viral cell cultures on Vero E6 cell strains are mentioned intimately to handle COVID-19. This evaluation additional gives an summary of emergency use licensed immunodiagnostic and molecular diagnostic kits and POC gadgets by FDA for well timed and environment friendly conduction of diagnostic checks. Nearly all of the literature cited on this paper is collected from tips on protocols and different issues on diagnostic methods of COVID-19 issued by WHO, CDC and FDA underneath emergency authorization.
Knowledgeable opinion: Such info holds significance to the well being professionals in conducting error-free diagnostic checks and researches in producing higher medical methods by addressing the constraints related to the obtainable strategies.
[Detoxification mechanism of Aconiti Lateralis Radix Praeparata combined with dried Rehmanniae Radix based on metabolic enzymes in liver]
The enzymes CYP1 A2 and CYP3 A4 had been measured by constructing a "Cocktail" probe drug and the incubation system of liver microsomes. The compatibility of Aconiti Lateralis Radix Praeparata mixed with dried Rehmanniae Radix on CYP450 enzyme protein and gene expression was explored from the extent of protein and molecular biology. It explored the molecular mechanism of compatibility detoxication of Aconiti Lateralis Radix Praeparata to offer scientific assist for medical secure and efficient utility of Aconiti Lateralis Radix Praeparata. The CYP450 enzyme exercise was decided through the use of "Cocktail" probe medication. The content material of CYP450 enzyme was measured by CO discount of differential spectrum technique. The mRNA expression of CYP1 A2 and CYP3 A4 enzyme was detected by RT-PCR expertise.
In contrast with the clean group, the CYP1 A2 and CYP3 A4 enzyme exercise and mRNA expression had been elevated within the dried Rehmanniae Radix mixed with Aconiti Lateralis Radix Praeparata group with vital variations(P<0.05), whereas the CYP3 A4 enzyme exercise and mRNA expression had been no affect within the Aconiti Lateralis Radix Praeparata group. The CYP3 A4 enzyme exercise and mRNA expression had been elevated within the dried Rehmanniae Radix and the dried Rehmanniae Radix mixed with Aconiti Lateralis Radix Praeparata group, and there have been vital variations(P<0.05).
Coelenterazine CP |
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| 10112-2 | Biotium | 250uG | EUR 257 |
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Description: N/A |
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Coelenterazine CP |
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| 10112-2-1 | Biotium | EA | EUR 257 |
CP-724714 |
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| A2412-100 | ApexBio | 100 mg | EUR 588.8 |
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Description: JAK/STAT Signaling|EGFR#Tyrosine Kinase|EGFR#Tyrosine Kinase|HER2 |
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CP-724714 |
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| A2412-25 | ApexBio | 25 mg | EUR 235.2 |
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Description: JAK/STAT Signaling|EGFR#Tyrosine Kinase|EGFR#Tyrosine Kinase|HER2 |
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CP-724714 |
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| A2412-5 | ApexBio | 5 mg | EUR 68 |
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Description: JAK/STAT Signaling|EGFR#Tyrosine Kinase|EGFR#Tyrosine Kinase|HER2 |
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CP-724714 |
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| A2412-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 73.6 |
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Description: JAK/STAT Signaling|EGFR#Tyrosine Kinase|EGFR#Tyrosine Kinase|HER2 |
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CP 471474 |
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| A4435-1 | ApexBio | 1mg | EUR 40 |
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Description: Proteases|MMP |
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CP 471474 |
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| A4435-10 | ApexBio | 10 mg | EUR 176 |
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Description: Proteases|MMP |
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CP 471474 |
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| A4435-5 | ApexBio | 5mg | EUR 104 |
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Description: Proteases|MMP |
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CP 471474 |
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| A4435-50 | ApexBio | 50 mg | EUR 842 |
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Description: Broad spectrum MMP inhibitor |
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CP-809101 |
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| A3330-10 | ApexBio | 10 mg | EUR 137.6 |
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Description: Neuroscience|5-HT Receptor |
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CP-809101 |
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| A3330-50 | ApexBio | 50 mg | EUR 591.2 |
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Description: Neuroscience|5-HT Receptor |
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CP-226269 |
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| 513641 | MedKoo Biosciences | 5.0mg | EUR 275 |
CP-105696 |
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| 524768 | MedKoo Biosciences | 5.0mg | EUR 265 |
CP-55940 |
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| 524805 | MedKoo Biosciences | 10.0mg | EUR 600 |
CP 66713 |
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| 524810 | MedKoo Biosciences | 5.0mg | EUR 280 |
CP-471474 |
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| 524847 | MedKoo Biosciences | 10.0mg | EUR 295 |
CP-532623 |
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| 524851 | MedKoo Biosciences | 5.0mg | EUR 300 |
CP-673451 |
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| 524866 | MedKoo Biosciences | 5.0mg | EUR 350 |
CP-868388 |
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| 524879 | MedKoo Biosciences | 5.0mg | EUR 320 |
CP-91149 |
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| 524881 | MedKoo Biosciences | 10.0mg | EUR 240 |
CP-281384 |
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| 525432 | MedKoo Biosciences | 5.0mg | EUR 270 |
CP-944629 |
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| 526348 | MedKoo Biosciences | 5.0mg | EUR 270 |
CP-316819 |
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| 574642 | MedKoo Biosciences | 10.0mg | EUR 330 |
CP 43 |
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| 584471 | MedKoo Biosciences | 10.0mg | EUR 360 |
CP-424174 |
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| 530552 | MedKoo Biosciences | 10.0mg | EUR 300 |
CP-74006 |
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| 530978 | MedKoo Biosciences | 500.0mg | EUR 350 |
CP-775146 |
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| 531747 | MedKoo Biosciences | 5.0mg | EUR 250 |
CP-380736 |
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| 561663 | MedKoo Biosciences | 5.0mg | EUR 255 |
CP-96345 |
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| 562171 | MedKoo Biosciences | 5.0mg | Ask for price |
CP-640186 |
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| 9422-25 | Biovision | each | EUR 666 |
CP-640186 |
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| 9422-5 | Biovision | each | EUR 222 |
CP-91149 |
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| A8403-10 | ApexBio | 10 mg | EUR 104.8 |
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Description: Metabolism|Phospholipase |
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CP-91149 |
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| A8403-25 | ApexBio | 25 mg | EUR 210.4 |
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Description: Metabolism|Phospholipase |
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CP-91149 |
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| A8403-5 | ApexBio | 5 mg | EUR 88 |
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Description: Metabolism|Phospholipase |
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CP-466722 |
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| A8625-10 | ApexBio | 10 mg | EUR 136 |
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Description: Cell Cycle/Checkpoint|ATM/ATR#DNA Damage/DNA Repair|ATM/ATR |
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CP-466722 |
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| A8625-5 | ApexBio | 5 mg | EUR 88 |
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Description: Cell Cycle/Checkpoint|ATM/ATR#DNA Damage/DNA Repair|ATM/ATR |
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CP-466722 |
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| A8625-50 | ApexBio | 50 mg | EUR 373.6 |
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Description: Cell Cycle/Checkpoint|ATM/ATR#DNA Damage/DNA Repair|ATM/ATR |
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CP Antibody |
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| 45875-100ul | SAB | 100ul | EUR 302.4 |
CP Antibody |
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| 45875-50ul | SAB | 50ul | EUR 224.4 |
CP 135807 |
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| 413313 | MedKoo Biosciences | 5.0mg | EUR 275 |
CP-690550 |
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| 410-06 | PHOENIX PEPTIDE | 10 mg | EUR 95.04 |
CP Antibody |
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| 46543 | SAB | 100ul | EUR 319 |
CP Antibody |
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| 46543-100ul | SAB | 100ul | EUR 302.4 |
CP-346086 |
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| 471083 | MedKoo Biosciences | 5.0mg | EUR 270 |
CP-335963 |
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| 471085 | MedKoo Biosciences | 1.0g | EUR 170 |
CP-101537 |
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| 471091 | MedKoo Biosciences | 10.0mg | EUR 90 |
CP Antibody |
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| ABD9369 | Lifescience Market | 100 ug | EUR 525.6 |
CP-609754 |
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| 206096 | MedKoo Biosciences | 10.0mg | EUR 450 |
CP-690550 |
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| 1622-25 | Biovision | each | EUR 738 |
CP-690550 |
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| 1622-5 | Biovision | each | EUR 255.6 |
CP-547632 |
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| 200810 | MedKoo Biosciences | 5.0mg | EUR 300 |
CP-724714 |
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| 200820 | MedKoo Biosciences | 5.0mg | EUR 250 |
CP Antibody |
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| DF9369 | Affbiotech | 200ul | EUR 420 |
CP Antibody |
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| DF9369-100ul | Affinity Biosciences | 100ul | EUR 168 |
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Description: WB,IHC,IF/ICC,ELISA(peptide) |
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CP Antibody |
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| DF9369-200ul | Affinity Biosciences | 200ul | EUR 210 |
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Description: WB,IHC,IF/ICC,ELISA(peptide) |
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CP-724714 |
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| B1333-25 | Biovision | each | EUR 940.8 |
CP-724714 |
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| B1333-5 | Biovision | each | EUR 314.4 |
CP-673451 |
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| B1337-1 | Biovision | each | EUR 288 |
CP-673451 |
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| B1337-5 | Biovision | each | EUR 810 |
CP-466722 |
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| B1722-1 | Biovision | each | EUR 183.6 |
CP-466722 |
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| B1722-5 | Biovision | each | EUR 418.8 |
CP-640186 |
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| B3585-10 | ApexBio | 10 mg | EUR 156 |
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Description: isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor |
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CP-640186 |
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| B3585-2 | ApexBio | 2 mg | EUR 64 |
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Description: isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor |
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CP-640186 |
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| B3585-5 | ApexBio | 5 mg | EUR 96 |
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Description: isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor |
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CP-640186 |
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| B3585-50 | ApexBio | 50 mg | EUR 616 |
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Description: isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor |
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CP 80633 |
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| B7162-.5 | ApexBio | 500ug | EUR 40 |
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Description: Metabolism|PDE |
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CP 80633 |
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| B7162-1 | ApexBio | 1mg | EUR 56 |
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Description: Metabolism|PDE |
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CP 80633 |
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| B7162-10 | ApexBio | 10 mg | EUR 392 |
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Description: Metabolism|PDE |
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CP 80633 |
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| B7162-5 | ApexBio | 5mg | EUR 228 |
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Description: Metabolism|PDE |
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CP 80633 |
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| B7162-50 | ApexBio | 50 mg | EUR 1019 |
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Description: PDE4 inhibitor |
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CP 154526 |
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| B7185-1 | ApexBio | 1 mg | EUR 66.4 |
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Description: GPCR/G protein|CRF1 Receptors |
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CP 154526 |
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| B7185-5 | ApexBio | 5 mg | EUR 103.2 |
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Description: GPCR/G protein|CRF1 Receptors |
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CP 96345 |
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| B7213-10 | ApexBio | 10 mg | EUR 472 |
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Description: Neuroscience|Substance P/NK1 Receptor |
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CP 96345 |
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| B7213-50 | ApexBio | 50 mg | EUR 1482.4 |
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Description: Neuroscience|Substance P/NK1 Receptor |
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CP-424174 |
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| B2531-1 | Biovision | each | EUR 157.2 |
CP-424174 |
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| B2531-5 | Biovision | each | EUR 405.6 |
CP 316819 |
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| B5448-10 | ApexBio | 10 mg | EUR 495.2 |
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Description: Metabolism|Phospholipase |
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CP 316819 |
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| B5448-50 | ApexBio | 50 mg | EUR 1493.6 |
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Description: Metabolism|Phospholipase |
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CP 20961 |
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| B5474-1 | ApexBio | 1mg | EUR 44 |
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Description: Others|Miscellaneous Compounds |
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CP 20961 |
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| B5474-10 | ApexBio | 10 mg | EUR 156 |
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Description: Others|Miscellaneous Compounds |
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CP 20961 |
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| B5474-25 | ApexBio | 25mg | EUR 340 |
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Description: Others|Miscellaneous Compounds |
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CP 20961 |
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| B5474-5 | ApexBio | 5mg | EUR 108 |
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Description: Others|Miscellaneous Compounds |
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CP 20961 |
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| B5474-50 | ApexBio | 50 mg | EUR 952 |
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Description: non-immunogenic adjuvant |
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CP-547632 |
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| B2056-500 | Biovision | each | EUR 183.6 |
CP-673451 |
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| B2173-10 | ApexBio | 10 mg | EUR 180 |
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Description: Tyrosine Kinase|VEGFR |
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CP-673451 |
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| B2173-200 | ApexBio | 200 mg | EUR 1672 |
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Description: Tyrosine Kinase|VEGFR |
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CP-673451 |
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| B2173-5 | ApexBio | 5 mg | EUR 95.2 |
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Description: Tyrosine Kinase|VEGFR |
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CP-673451 |
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| B2173-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 128 |
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Description: Tyrosine Kinase|VEGFR |
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CP-673451 |
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| B2173-50 | ApexBio | 50 mg | EUR 543.2 |
|
Description: Tyrosine Kinase|VEGFR |
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CP-544326 |
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| B1121-25 | Biovision | each | EUR 666 |
CP-544326 |
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| B1121-5 | Biovision | each | EUR 222 |
CP 135807 |
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| B7497-10 | ApexBio | 10 mg | EUR 270.4 |
|
Description: GPCR/G protein|5-HT Receptor |
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CP 135807 |
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| B7497-50 | ApexBio | 50 mg | EUR 1096 |
|
Description: GPCR/G protein|5-HT Receptor |
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CP 775146 |
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| B7609-1 | ApexBio | 1mg | EUR 40 |
|
Description: Metabolism|PPAR |
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CP 775146 |
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| B7609-10 | ApexBio | 10 mg | EUR 268 |
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Description: Metabolism|PPAR |
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CP 775146 |
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| B7609-25 | ApexBio | 25mg | EUR 588 |
|
Description: Metabolism|PPAR |
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CP 775146 |
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| B7609-5 | ApexBio | 5mg | EUR 156 |
|
Description: Metabolism|PPAR |
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CP 775146 |
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| B7609-50 | ApexBio | 50 mg | EUR 1234 |
|
Description: PPARα agonist |
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CP Antibody |
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| CSB-PA361096XA01OAM-02mg | Cusabio | 0.2mg | Ask for price |
|
Description: Recombinant Odontoglossum ringspot virus (isolate Japan) (ORSV) CP protein |
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CP Antibody |
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| CSB-PA361096XA01OAM-10mg | Cusabio | 10mg | Ask for price |
|
Description: Recombinant Odontoglossum ringspot virus (isolate Japan) (ORSV) CP protein |
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CP Antibody |
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| 1-CSB-PA14599A0Rb | Cusabio |
|
|
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Description: A polyclonal antibody against CP. Recognizes CP from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
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CP Antibody |
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| CAC09179-100ug | Biomatik Corporation | 100ug | EUR 314 |
CP Antibody |
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| CAC09179-50ug | Biomatik Corporation | 50ug | EUR 199.2 |
CP 640186 |
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| C591780 | Toronto Research Chemicals | 100mg | EUR 4500 |
|
Description: 591778-68-6 |
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CP-10447 |
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| C781200 | Toronto Research Chemicals | 10mg | EUR 201 |
|
Description: 843-93-6 |
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CP 96345 |
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| C781210 | Toronto Research Chemicals | 250mg | EUR 9200 |
|
Description: 132746-60-2 |
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(±)-CP 55940 |
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| C781225 | Toronto Research Chemicals | 0.5mg | EUR 1518 |
CP-141938 |
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| C781290 | Toronto Research Chemicals | 100mg | EUR 12800 |
|
Description: 182822-62-4 |
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CP-316819 |
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| C781300 | Toronto Research Chemicals | 10mg | EUR 356 |
CP-471474 |
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| C781305 | Toronto Research Chemicals | 5mg | EUR 86 |
|
Description: 210755-45-6 |
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CP-47497 |
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| C781310 | Toronto Research Chemicals | 10mg | EUR 69 |
(-)-CP-47947 |
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| C781325 | Toronto Research Chemicals | 25mg | EUR 31000 |
|
Description: 114753-51-4 |
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CP-775146 |
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| C781355 | Toronto Research Chemicals | 10mg | EUR 230 |
|
Description: 702680-17-9 |
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CP-91149 |
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| C781360 | Toronto Research Chemicals | 100mg | EUR 76 |
|
Description: 186392-40-5 |
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CP 724714 |
|||
| C781365 | Toronto Research Chemicals | 250mg | EUR 4500 |
|
Description: 383432-38-0 |
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CP-466722 |
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| C781395 | Toronto Research Chemicals | 10mg | EUR 1200 |
|
Description: 1080622-86-1 |
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CP-481715 |
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| C781405 | Toronto Research Chemicals | 100mg | EUR 9200 |
|
Description: 212790-31-3 |
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(+)-CP 55940 |
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| C781415 | Toronto Research Chemicals | 25mg | EUR 27000 |
|
Description: 83002-05-5 |
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CP Antibody |
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| CSB-PA886137XA01FRS-02mg | Cusabio | 0.2mg | Ask for price |
|
Description: Recombinant Ribgrass mosaic virus (RMV) CP protein |
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CP Antibody |
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| CSB-PA886137XA01FRS-10mg | Cusabio | 10mg | Ask for price |
|
Description: Recombinant Ribgrass mosaic virus (RMV) CP protein |
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CP-547632 |
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| MBS131064-100mg | MyBiosource | 100mg | EUR 1065 |
CP-547632 |
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| MBS131064-500mg | MyBiosource | 500mg | EUR 2775 |
CP-724714 |
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| MBS131447-100mg | MyBiosource | 100mg | EUR 1495 |
CP-91149 |
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| MBS131451-100mg | MyBiosource | 100mg | EUR 1065 |
CP-91149 |
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| MBS131451-500mg | MyBiosource | 500mg | EUR 2775 |
CP 640186 |
|||
| MBS130359-100mg | MyBiosource | 100mg | EUR 1065 |
CP 640186 |
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| MBS130359-500mg | MyBiosource | 500mg | EUR 2775 |
CP 466722 |
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| MBS132498-100mg | MyBiosource | 100mg | EUR 1065 |
CP 466722 |
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| MBS132498-500mg | MyBiosource | 500mg | EUR 2775 |
CP 724714 |
|||
| MBS132265-100mg | MyBiosource | 100mg | EUR 1065 |
CP 724714 |
|||
| MBS132265-500mg | MyBiosource | 500mg | EUR 2775 |
CP-945598 |
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| MBS132331-100mg | MyBiosource | 100mg | EUR 1065 |
CP-945598 |
|||
| MBS132331-500mg | MyBiosource | 500mg | EUR 2775 |
CP 673451 |
|||
| MBS132201-100mg | MyBiosource | 100mg | EUR 1065 |
CP 673451 |
|||
| MBS132201-500mg | MyBiosource | 500mg | EUR 2775 |
CP-447697 |
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| HY-112199 | MedChemExpress | 10 mg | EUR 568.19 |
|
Description: CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation[1]. |
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CP-195543 |
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| HY-112742 | MedChemExpress | Get quote | Ask for price |
|
Description: CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration[1]. |
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CP-67804 |
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| HY-113642 | MedChemExpress | Get quote | Ask for price |
|
Description: CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent[1]. |
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CP-346086 |
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| HY-113955 | MedChemExpress | 10 mg | EUR 270.57 |
|
Description: CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo[1]. |
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CP-07 |
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| HY-149495 | MedChemExpress | Get quote | Ask for price |
|
Description: CP-07 is a potent and selective PROTACCDK9 degrader (DC50: 43 nM). CP-07 inhibits 22RV1 cell proliferation (IC50: 62 nM) and colony formation by down-regulating Mcl-1 and c-Myc. CP-07 inhibits 22RV1 xenograft tumor growth. CP-07 can be used for research of prostate cancer[1]. |
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CP-506 |
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| HY-149769 | MedChemExpress | Get quote | Ask for price |
|
Description: CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity[1]. |
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CP-28888 |
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| HY-U00008 | MedChemExpress | 5mg | EUR 1960.8 |
CP-060 |
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| HY-U00354 | MedChemExpress | 5mg | EUR 4292.4 |
CP-640186 |
|||
| HY-15259 | MedChemExpress | 100mg | EUR 519.49 |
|
Description: CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation[1][2]. |
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CP-91149 |
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| HY-13525 | MedChemExpress | 10 mg | EUR 324.68 |
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Description: CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study[1]. |
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CP-96486 |
|||
| HY-100316 | MedChemExpress | 1mg | EUR 2128.8 |
|
Description: CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. |
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CP 375 |
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| HY-100332 | MedChemExpress | 1mg | EUR 1870.8 |
|
Description: CP 375 is a Fe3+ chelating agent, with a log K1 value of 14.50. |
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The content material of CYP450 enzyme was decreased within the Aconiti Lateralis Radix Praeparata group, contributed to extraordinarily vital distinction(P<0.01). The content material of CYP450 enzyme was elevated within the dried Rehmanniae Radix and the dried Rehmanniae Radix mixed with Aconiti Lateralis Radix Praeparata group, and there have been vital variations(P<0.05). The CYP1 A2 and CYP3 A4 enzyme exercise and gene expression had been enhanced after dried Rehmanniae Radix mixed with Aconiti Lateralis Radix Praeparata. The metabolism of poisonous substances of Aconiti Lateralis Radix Praeparata was accelerated to achieve an impact of detoxication. The detoxication mechanism of compatibility of Aconiti Lateralis Radix Praeparata was verified from the perspective of liver metabolic enzymes.
